Therapeutic compounds and related methods of use

A compound of formula (III):

• or a salt thereof,
• wherein:
• A is N;
• L is NR6;
• one of X1, X2, X3, X4 and X5 is N and the others are CH;
• m is 1;
• n is 0 or 1;
• R1 is hydrogen, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, alkoxyalkyl, hydroxyalkyl, imidazolyl, furylalkyl, pyridylalkyl, phenylalkyl, oxazolylalkyl, thienylalkyl, thiazolidinyl, isoindolyl, —C(O)Re, dihydroindenyl, C3-C8 cycloalkyl, C3-C8 cycloalkylalkyl, piperidyl, morpholinyl, pyrrolidinyl, azetidinyl or piperazinyl, each of which is optionally substituted with 1-3 R7;
• R2 is phenyl, naphthyl, benzofuryl, indazolyl, benzothienyl, pyridyl, pyrimidinyl, dihydrobenzodioxinyl, benzodioxolyl, benzoimidazolyl, isoxazolyl, pyrazolyl, indolinyl or benzisoxazolyl, each of which is optionally substituted with 1-5 R9;
• each R3 or R4 is independently hydrogen, C1-C8 alkyl, halo, haloalkyl or —ORd;
• R6 is hydrogen or C1-C8 alkyl;
• each R7 and R9 is independently C1-C8 alkyl, phenyl, halo, haloalkyl, haloalkoxy, hydroxyalkyl, alkoxyalkyl, oxo, —CN, —NO2, —C(O)ORa, —C(O)NRbRb′, —NRbRb′, —ORd, —C(O)Re or —S(O)qRf, each of which is optionally substituted with 1-3 R12;
• R12 is independently C1-C8 alkyl, oxo, halo, haloalkyl, —CN, —C(O)NRbRb′ or —C(O)Re, each of which is optionally substituted with 1-3 R13;
• R13 is independently C1-C8 alkyl, halo or pyrrolidinyl;
• and
• each Ra, Rb, Rb′, Rc, Rc′, Rd, Rd′, Re and Rf is independently hydrogen, C1-C8 alkyl, C3-C8 cycloalkyl, pyrrolidinyl, piperidyl, morpholinyl, piperazinyl, tetrahydropyranyl, phenylalkyl, alkoxyalkyl, morpholinylalkyl, oxazolidinylalkyl, imidazolylalkyl, tetrahydropyranylalkyl, pyridylalkyl, pyrazolylalkyl, tetrazolylalkyl, thiazolylalkyl, pyrrolylalkyl, benzoxazolylalkyl, indazolylalkyl, dihydrobenzoxazinylalkyl, tetrahydrofurylalkyl, tetrahydrofuryl, alkylaminoalkyl, dialkylaminoalkyl or phenyl.