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US 2015/0307476 A1Published application
Crizotinib Preparation Method
AssigneeZhejiang Jiuzhou Pharmaceutical Co., Ltd.
InventorsYuanqiang LI, Jianqiang QIAN, Daqing CHE
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Abstract
The present invention relates to the technical field of medicine and organic synthesis, particularly to a method for preparing crizotinib. The method comprises the compound of formula b and the compound of formula e undergoing Suzuki coupling reaction to produce the compound of formula a which then was subjected to deprotection to afford (±) crizotinib.
Claims10
A method for preparing the compound of formula a, comprising Suzuki coupling reaction of the compound of formula b with the compound of formula e to produce the compound of formula a,
- Wherein, R is a protecting group, the protecting group is Boc or Cbz;
- both R1 and R2 are hydrogen or methyl, or are incorporated into the group having the following formula M:
Dependencies are inferred from the claim text.