Autotaxin inhibitors

A compound of formula (I)

• or a pharmaceutically acceptable salt thereof, wherein
• A is selected from
• A′ is selected from O, S and NR2a;
• A″ is selected from O and S;
• Y1 is —(CR2bR2c)m— or CH═CH—;
• X is selected from —C(═O)—, —N(R3)—C(═O)—, —C(═O)—N(R3)—, —N(R3)— and —CH2—;
• Y2 is —(CR4aR4b)n—;
• m is selected from 0, 1, 2, 3, 4 and 5;
• n is selected from 0, 1, 2, 3, 4 and 5;
• wherein when Y1 is —(CR2bR2c)m— and A is not HO—C(═O)—, the sum of m and n is not less than 2 and no more than 5;
• and
• wherein when Y1 is —(CR2bR2c)m— and A is HO—C(═O)—, the sum of m and n is not less than 2 and no more than 7;
• or
• A-Y1—X— is
• L is selected from
• W is CH or N;
• Z is selected from CH2, O and NR5c;
• Y3 is selected from —O—(CR6aR6b)—, —(CR6cR6d)—O—, —CH═CH—, —CR6eR6f—CR6gR6h—, and —O—(CR6iR6j—CR6kR6l)—;
• R1a, R1b, R1c, R1d and R1e are defined according to any one of
• (a) R1b is halogen;
• R1d is halogen, CN, C1-4alkyl, C1-4haloalkyl or C1-4haloalkoxy;
• and R1a, R1c and R1e are H;
• (b) R1b is halogen;
• R1d is halogen, CN, C1-4alkyl, C1-4haloalkyl or C1-4haloalkoxy;
• R1c is halogen;
• and R1a and R1e are H;
• (c) R1b is C1-4alkyl;
• R1d is C1-4alkyl, C1-4haloalkyl, C1-4haloalkoxy or CN;
• R1a, R1c and R1e are H;
• (d) R1b is CN;
• R1d is C1-4haloalkyl or C1-4haloalkoxy;
• and R1a, R1c and R1e are H;
• (e) R1b is C1-4haloalkyl or C1-4haloalkoxy;
• and R1a, R1c and R1e are H;
• and R1d is H or CN;
• (f) R1a is halogen;
• R1c is halogen, CN, C1-4alkyl, C1-4haloalkyl or C1-4haloalkoxy;
• and R1b, R1d and R1e are H;
• (g) R1c is halogen, CN, C1-4alkyl, C1-4haloalkyl or C1-4haloalkoxy;
• and R1a, R1b and R1e are H;
• and R1d is halogen, CN, C1-4alkyl, C1-4haloalkyl, C1-4haloalkoxy, or H;
• R2 is selected from H, C1-4alkyl and halogen;
• R2a, R2b, R2c, R3, R4a, R4b, R4c, R4d, R5a, R5b, R5c, R6a, R6b, R6c, R6d, R6e, R6f, R6g, R6h, R6i, R6j, R6k and R6l are independently selected from H and C1-4alkyl.