Therapeutic compounds and compositions and their use as pkm2 modulators

A compound of Formula (I):

• or a pharmaceutically acceptable salt thereof, wherein:
• A is aryl or heteroaryl, wherein the aryl or heteroaryl is optionally substituted, and the aryl or heteroaryl is optionally fused to an optionally substituted carbocyclyl or an optionally substituted heterocyclyl;
• X is selected from —NH—S(O)2—, —N(alkyl)-S(O)2—, —S(O)2—NH— and —S(O)2—N(alkyl)-;
• R1b is C2-8 alkyl, cycloalkyl, aryl, heteroaryl, cycloalkylalkyl, aralkyl or heteroaralkyl, wherein each aryl is substituted and each C2-8 alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, heteroaryl or heteroaralkyl is optionally substituted;
• each R2 is independently selected from halo and haloalkyl;
• each R4 is independently selected from alkyl, alkoxy, haloalkyl and hydroxyl;
• n is 0, 1 or 2;
• and
• m is 0, 1 or 2;
• wherein when R1b is unsubstituted benzyl, X is —NH—S(O)2— and A is quinolin-8-yl;
• then n is 1.