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US 2015/0307463 A1Published application
Substituted isoxazole amide compounds as inhibitors of stearoyl-coa desaturase 1 (scd1)
AssigneeHoffmann-La Roche Inc.
InventorsShawn David Erickson, Paul Gillespie, Eric Mertz
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Abstract
The invention is concerned with a compound of formula (I) and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and using the compound of formula (I) as well as pharmaceutical compositions containing such compounds. The compound of formula (I) are SCD1 inhibitors and may be useful in treating cancer.
Claims15
A compound of formula (I)
- wherein:
- A is —CH— or nitrogen;
- R1 is —O—CH2—R3, —CH2—O—R3 or —CH2—R4;
- R2 is hydrogen or halogen;
- R3 is -phenyl, optionally mono- or bi-substituted independently with lower alkyl, alkoxy, halogen, —CN, —CF3, —OCF3, —SCF3, —S(═O)CF3 or —SO2CH3, or
- -pyridinyl, optionally substituted with lower alkyl or halogen;
- and
- R4 is indolyl, dihydroindolyl, isoindolyl, dihydroisoindolyl, benzotriazolyl, benzoimidazolyl, indazolyl, tetrahydroquinolinyl, methyldihydroindolyl or methylindolyl;
- or a pharmaceutically acceptable salt thereof.
6 more elements
13-16. (canceled)
(canceled)
Dependencies are inferred from the claim text.