Glycine transporter-1 inhibitors
AssigneeAmgen Inc.
InventorsStephen A. Hitchcock, Albert Amegadzie, Wenyuan Qian, Xiaoyang Xia, Scott S. Harried
Life of this patent
Estimating the term…
Abstract
The present invention provides compounds that are glycine transporter 1 (hereinafter referred to as GlyT-1) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of GlyT1 such as cognitive disorders associated with Schizophrenia, ADHD (attention deficit hyperactivity disorder), MCI (mild cognitive impairment), and the like. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
Claims21
1-27. (canceled)
A compound of Formula (I):
- having the formula:
- wherein:
- R1 is hydrogen and R2 is methyl, ethyl, propyl, trifluoromethyl, 2,2,2-trifluoroethyl, methoxy, ethoxy, propoxy, trifluoromethoxy, difluoromethoxy, or 2,2,2-trifluoroethoxy;
- R3, R4 and R5 are independently hydrogen, alkyl, fluoro, or fluoroalkyl;
- and
- Ar1 and Ar2 are independently aryl, heteroaryl, cycloalkyl, or heterocyclyl wherein each of the aforementioned ring is optionally substituted with Rg, Rh or Ri where Rg is alkyl, halo, haloalkyl, haloalkoxy, alkylthio, cyano, alkoxy, amino, monosubstituted amino, disubstituted amino, sulfonyl, acyl, carboxy, alkoxycarbonyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, hydroxyalkoxy, alkoxyalkoxy, aminoalkoxy, aminosulfonyl, aminocarbonyl, or acylamino and Rh and Ri are independently selected from alkyl, halo, haloalkyl, haloalkoxy, alkylthio, cyano, alkoxy, amino, monosubstituted amino, disubstituted amino, sulfonyl, acyl, carboxy, alkoxycarbonyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, hydroxyalkoxy, alkoxyalkoxy, aminoalkoxy, aminosulfonyl, aminocarbonyl, acylamino, aryl, heteroaryl, cycloalkyl, or heterocyclyl wherein the aromatic or alicyclic ring in Rg, Rh and Ri is optionally substituted with Rj, Rk or Rl which are independently selected from alkyl, halo, haloalkyl, haloalkoxy, alkylthio, cyano, alkoxy, amino, monosubstituted amino, disubstituted amino, sulfonyl, acyl, carboxy, alkoxycarbonyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, hydroxyalkoxy, alkoxyalkoxy, aminoalkoxy, aminosulfonyl, aminocarbonyl, or acylamino;
- or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition comprising a compound of Formula (I) according to any one of the preceding claims, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.