Sulfonamide Compound

The compound according to any one of claims 1 to 3 or 17, wherein

• Ring A is the formula (i) or formula (ii),
• R4 is C1-C6 alkyl, and
• X1 and X2 are each independently the following formula (iii), (iv), (v), (vi), or (vii):
• wherein R5 is a hydrogen atom, C1-C6 alkyl, or C1-C6 halogenoalkyl, and V1 is NH or O, or
• R4 and X2 combine with each other at their terminals together with the adjacent benzene to form the following formula (viii):
• wherein V2 is NH or O,
• or a pharmaceutically acceptable salt thereof.

The compound according to any one of claims 1 to 3 or 17, wherein

• Ring A is the formula (i) or formula (ii),
• R4 is C1-C6 alkyl,
• X1 and X2 are each independently the following formula (iii), (iv), (v-a), or (vii-a):
• wherein R5a is a hydrogen atom or C1-C6 alkyl, or
• R4 and X2 combine with each other at their terminals together with the adjacent benzene to form the following formula (viii-a):
• Y1 is CH, and
• Y2 is CH or N,
• or a pharmaceutically acceptable salt thereof.

A compound selected from the group consisting of

• N-(4-cyclopropylisoquinolin-3-yl)-4-(5-oxo-4,5-dihydro-1 H-tetrazol-1-yl)-N-[4-(trifluoromethoxy)benzyl]benzenesulfonamide;
• N-(4-cyclopropylisoquinolin-3-yl)-6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-N-[4-(trifluoromethoxy)benzyl]pyridine-3-sulfonamide;
• N-(4-(trifluoromethyl)isoquinolin-3-yl)-6-(1H-1,2,4-triazol-5-yl)-N-[4-(trifluoromethoxy)benzyl]pyridine-3-sulfonamide;
• N-(4-(trifluoromethyl)isoquinolin-3-yl)-6-(3-methyl-1H-1,2,4-triazol-5-yl-N-[4-(trifluoromethoxy)benzyl]pyridine-3-sulfonamide;
• 4-({(4-cyclopropylisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)-2-methylbenzoic acid;
• and
• 4-({(4-cyclopropylisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)-2-(dimethylamino)benzoic acid,
• or a pharmaceutically acceptable salt thereof.