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US 2015/0307452 A1Published application
Novel pyridine derivatives
AssigneeHoffmann-La Roche Inc.
InventorsBeat FREI, Luca GOBBI, Uwe GRETHER, Atsushi KIMBARA, Matthias NETTEKOVEN, Stephan ROEVER, Mark ROGERS-EVANS, Tanja SCHULZ-GASCH
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Abstract
The invention relates to a compound of formula (I) wherein R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
Claims21
A compound of formula (I)
- wherein
- R1 is halogen, cycloalkylalkoxy, haloalkoxy, alkylsulfonyl, alkylsulfinyl, halophenylalkyl, alkylsulfanyl, oxanylalkoxy, halophenyl or oxolanylalkoxy;
- R2 is halogen, cycloalkyl, haloalkyl, haloalkoxy, haloazetidinyl, cycloalkyloxy, halocycloalkyl, hydroxycycloalkyl, hydroxyazetidinyl, hydroxyoxetanyl or halooxetanyl;
- R3 is (alkyl)(oxo)pyrrolidinyl or —C(R4R5)—C(R6R7)—C(O)—R8;
- R4 and R5 are independently selected from hydrogen, alkyl, phenyl, phenylalkyl, cycloalkyl, tetrahydropyranyl, haloalkyl, halophenyl and oxolanyl;
- or R4 and R5 together with the carbon atom to which they are attached form cycloalkyl, oxetanyl, thiethanyl, 1,1-dioxo-1λ6-thiethanyl, azetidinyl, haloazetidinyl, 2-oxa-spiro[3.3]heptyl, tetrahydrofuranyl, pyrrolidinyl, oxopyrrolidinyl, 1,1-dioxo-1λ6-isothiazolidinyl, 1,1-dioxo-tetrahydro-1λ6-thiophenyl, tetrahydrothiophenyl, tetrahydropyranyl, piperidinyl, oxopiperidinyl, tetrahydrothiopyranyl, 2-oxo-[1,3]oxazinanyl, 1,1-dioxo-1λ6-[1,2]thiazinanyl, 2-oxo-hexahydro-pyrimidinyl, 1,1-dioxo-hexahydro-1λ6-thiopyranyl, 2-oxo-[1,3]dioxanyl, 1,1-dioxothianyl, alkylcarbonylpiperidinyl, alkylcarbonylazetidinyl, phenylalkyloxycarbonylazetidinyl, oxolanyl, or phenylalkyloxycarbonylpyrrolidinyl;
- R6 and R7 are independently selected from hydrogen and alkyl;
- or one of R4 and R5 and one of R6 and R7, together with the carbon atoms to which they are attached, form cycloalkyl, and the other ones are both hydrogen at the same time;
- and
- R8 is —NH2, alkoxy, alkylamino or hydroxyl;
- or a pharmaceutically acceptable salt or ester thereof.
8 more elements
(canceled)
-21. (canceled)
(canceled)
Dependencies are inferred from the claim text.