Nitrogen-containing heterocyclic compound
AssigneeTakeda Pharmaceutical Company Limited
InventorsMasami YAMADA, Shinkichi SUZUKI, Takahiro SUGIMOTO, Minoru NAKAMURA, Hiroki SAKAMOTO, Makoto KAMATA
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Abstract
The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the prophylaxis or treatment of Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies, and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof. wherein each symbol is as described in the specification, or a salt thereof.
Claims23
A compound represented by the formula (I):
- wherein
- R1 is an optionally substituted 5- or 6-membered cyclic group or an optionally substituted C1-6 alkyl group;
- R2 and R3 are the same or different and each is a hydrogen atom, a halogen atom, a cyano group, an optionally substituted C1-6 alkyl group, an optionally substituted C1-6 alkoxy group or an optionally substituted C3-6 cycloalkyl group;
- R4 is a halogen atom, a cyano group, an optionally substituted C1-6 alkyl group, an optionally substituted C1-6 alkoxy group, an optionally substituted carbamoyl group or an optionally substituted 3- to 8-membered cyclic group;
- and
- Ring A is an optionally further substituted 6-membered aromatic ring,
- or a salt thereof.
2-[(3S,4S)-4-Hydroxytetrahydro-2H-pyran-3-yl]-6-(4-methoxybenzyl)-4,5-dimethyl-2,3-dihydro-1H-isoindol-1-one, or a salt thereof.
4-Fluoro-2-[(3S,4S)-4-hydroxytetrahydro-2H-pyran-3-yl]-5-methyl-6-[4-(1H-pyrazol-1-yl)benzyl]-2,3-dihydro-1H-isoindol-1-one, or a salt thereof.
2-((1S,2S)-2-Hydroxycyclohexyl)-4,5-dimethyl-6-((6-methylpyridin-3-yl)methyl)isoindolin-1-one, or a salt thereof.
Dependencies are inferred from the claim text.