New compounds and uses thereof
AssigneeBiostatus Limited
InventorsStefan Ogrodzinski, Paul Smith, Stephanie McKeown, Laurence Patterson, Rachel Jane Errington
Life of this patent
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Abstract
An anthraquinone compound of formula I (such as the compounds of formulae II to X) and processes for making the same are provided. Pharmaceutical compositions for use in the treatment of cancer, optionally in combination with an agent capable of reducing the level of oxygenation of a tumour, are also provided. Additionally, an option for combination with chemotherapeutic and radiotherapeutic modalities to enhance overall tumour cell kill is provided. Methods for the detection of cellular hypoxia, both in vivo and in vitro, are additionally provided.
Claims85
A compound of Formula I
- wherein X1, X2, X3 and X4 are each independently selected from the group consisting of hydrogen, hydroxy, halogeno, amino, C1-4 alkoxy, C2-8 alkanoyloxy, —NH-A-NHR, —NH-A-NR′R″ and —NH-A-N(O) R′R″
- wherein A is an alkylene group with a chain length of at least two carbon atoms (between NH and NHR or N(O)R′R″),
- wherein R, R′ and R″ are each independently selected from C1-4 alkyl groups and C2-4 hydroxyalkyl and C2-4 dihydroxyalkyl groups in which the carbon atom attached to the nitrogen atom does not carry a hydroxy group and no carbon atom is substituted by two hydroxy groups, or wherein R and R″ together are a C2-6 alkylene group which with the nitrogen atom to which R′ and R″ are attached forms a heterocyclic group having 3 to 7 atoms in the ring,
- wherein at least one of X1, X2, X3 and X4 is selected from the group consisting of deuterated forms of —NH-A-NHR, —NH-A-NR′R″ and —NH-A-N(O) R′R″.
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The kit according to claim 7170 further comprising a non-deuterated form of a compound according to claim 1.
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Dependencies are inferred from the claim text.