Rotational Localized Drug Delivery Device

A method to deliver a drug to a lumen wall comprising

• advancing a drug delivery device to a treatment site, the drug delivery device comprising:
• an impeller, the impeller comprising:
• an impeller housing positioned at a distal end of a housing shaft, the impeller housing and the housing shaft each defining a lumen, the impeller housing comprising a side opening for passage of a drug therethrough;
• a rotatable impeller head positioned at a distal end of an impeller shaft, the impeller head positioned in the lumen of the impeller housing, the impeller shaft positioned in the lumen defined by the housing shaft;
• a drug lumen for passage of a drug to the rotatable impeller head;
• advancing a drug through the drug lumen to the impeller head;
• and
• rotating the impeller head to deliver the drug by centrifugal force.