Tissue removal devices, systems and methods

A tissue removal device, comprising:

• a housing;
• a rigid aspiration cannula extending from the housing to a distal tip outside the housing, the distal tip having a distal opening;
• a valve disposed in the housing, the valve comprising a valve port communicating with the aspiration cannula in a fluid-sealed manner;
• an aspiration line communicating with the valve and passing through the housing of the tissue removal device to provide a fluid connection between the aspiration cannula and a collection receptacle comprising a canister interior, an aspiration inlet communicating with the aspiration line and the cassette interior, and a vacuum outlet communicating with the cassette interior and configured for communication with a vacuum source, wherein the vacuum source creates a vacuum in a fluid circuit comprising the collection receptacle, the aspiration line, and the aspiration cannula, the valve being controlled to open and close to provide a pulsed vacuum.