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US 2015/0306256 A1Published application
Lanthanide Nanoparticle Conjugates and Uses Thereof
AssigneesColorado School of Mines, Colorado State University Research Foundation
InventorsStephen G. Boyes, Misty D. Rowe, Douglas H. Thamm, Susan L. Kraft
Life of this patent
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Abstract
The present disclosure is directed generally to lanthanide nanoparticle conjugates, such as gadolinium nanoparticle conjugates, nanoparticle conjugates including polymers, conjugation to targeting agents and therapeutic agents, and their use in targeting, treating, and/or imaging disease states in a patient.
Claims21
1-14. (canceled)
A lanthanide nanoparticle conjugate comprising:
- a lanthanide nanoparticle, and
- a polymer, polymer precursor, or initiator grafted onto the nanoparticle, wherein the polymer, polymer precursor, or initiator comprises a functional group that is the point of attachment to the lanthanide nanoparticle.
A method of increasing the stability of a lanthanide nanoparticle conjugate comprising:
- grafting a polymer having one of the following formulas:
- onto a lanthanide nanoparticle to form a lanthanide nanoparticle conjugate, wherein the lanthanide nanoparticle conjugate is twice as resistant to digestion as the lanthanide nanoparticle.
Dependencies are inferred from the claim text.