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US 2015/0306253 A1Published application
Dual emissive metal nanoparticles as ratiometric ph indicators
AssigneeBoard of Regents, The University of Texas System
InventorsJie ZHENG, Jinbin LIU
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Abstract
In some aspects, the present disclosure provides a dual emissive pH response noble metal nanoparticle which produces a ratiometric fluorescence signal based upon changes in the pH. In another aspect, the noble metal nanoparticle may be used in bioimaging applications as well as to detect in vivo changes of pH.
Claims22
A nanoparticle comprising a noble metal nanoparticle, wherein:
- the noble metal nanoparticle is about 0.1 nm to about 5 nm in diameter;
- the noble metal nanoparticle comprises a mixture of metal atoms in the ground oxidation state and a charged oxidation state;
- and
- the surface of the noble metal nanoparticle is coated with a first pH-dependent ligand.
1 more element
Dependencies are inferred from the claim text.