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US 2015/0306241 A1Published application
Copolymers for the delivery of drugs into cells
AssigneeNortheastern University
InventorsLin Zhu, Federico Perche, Vladimir P Torchilin
Life of this patent
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Abstract
Provided is a co-polymer of formula A-B-C or a pharmaceutically acceptable salt thereof, where A comprises a water soluble polymer; B comprises a matrix metalloprotease (MMP)-cleavable polypeptide; C is a chemotherapeutic drug or a derivative thereof; and A is connected to B at a first end through a first covalent bond or a first linking moiety and B is connected to C at a second end through a second covalent bond or a second linking moiety, where the co-polymer is not cross-linked.
Claims27
A co-polymer of formula (I)
- A-B-C (I)
- or a pharmaceutically acceptable salt thereof, wherein
- A comprises a water soluble polymer;
- B comprises a matrix metalloprotease (MMP)-cleavable polypeptide;
- C is a chemotherapeutic drug or a derivative thereof;
- and
- A is connected to B at a first end through a first covalent bond or a first linking moiety and B is connected to C at a second end through a second covalent bond or a second linking moiety, and wherein the co-polymer is not cross-linked.
4 more elements
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Dependencies are inferred from the claim text.