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AssigneeThe Regents of the University of Michigan
InventorsJames R. Baker, Seok Ki Choi, Andrzej Myc
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The present invention relates to bacteria-targeting nanoparticles and related methods of use. In particular, the present invention relates to dendrimer nanoparticles conjugated with Vancomycin and/or Polymixin (e.g., Polymixin B, Polymixin E). In certain embodiments, such dendrimer nanoparticles are used to sequester and/or identify bacteria (e.g., Gram-positive bacteria and/or Gram-negative bacteria), screen liquid samples (e.g., water samples, food samples, pharmaceutical samples, blood samples, blood platelet samples, etc.) for the presence of bacteria (e.g., Gram-positive bacteria and/or Gram-negative bacteria), treat disorders associated with bacteria (e.g., Gram-positive bacteria and/or Gram-negative bacteria), and/or identify, sequester, and remove bacteria (e.g., Gram-positive bacteria and/or Gram-negative bacteria) from a liquid sample (e.g., water sample, food sample, pharmaceutical sample, blood sample, blood platelet sample, etc.). In certain embodiments, iron oxide nanoparticles are coated with dendrimer nano-particles conjugated with Vancomycin and/or Polymixin.
1-45. (canceled)
A method for treating a Gram-positive and/or Gram-negative bacterial disorder, comprising administering to a subject suspected of having a Gram-positive and/or Gram-negative bacterial disorder a composition comprising dendrimer nanoparticles conjugated with Vancomyocin and/or Polymyxin B or E molecules, wherein said dendrimer nanoparticles bind with Gram-positive and/or Gram-negative bacteria, wherein said binding results in the amelioration of symptoms related to the Gram-positive and/or Gram-negative bacterial disorder, wherein said subject is a mammal.
A method for detecting the presence of Gram-positive and/or Gram-negative bacteria in a sample, comprising administering to said sample a composition comprising dendrimer nanoparticles conjugated with Vancomyocin and/or Polymyxin B or E molecules molecules and imaging agents, wherein upon said administering said dendrimer nanoparticles bind with said Gram-positive and/or Gram-negative bacteria, and detecting the imaging agents within said sample bound with said Gram-positive and/or Gram-negative bacteria.
A method for sequestering Gram-positive and/or Gram-negative bacteria within a sample, comprising administering compositions comprising iron oxide nanoparticles coated with dendrimer nanoparticles conjugated with Vancomycin or Polymyxin B or E alone, or in combination to said sample such that said iron oxide nanoparticles bind with said Gram-positive and/or Gram-negative bacteria, and sequestering said iron oxide nanoparticles bound with said Gram-positive and/or Gram-negative bacteria through administration of a magnetic field and/or centrifugation to said sample.
Dependencies are inferred from the claim text.