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US 2015/0306234 A1Published application
MUTEINS OF CLOTTING FACTOR Vlll
AssigneePfizer Inc.
InventorsJames Apgar, Debra Pittman, Mark Stahl, Laura Lin, Justin Cohen
Life of this patent
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Abstract
The present disclosure provides muteins of FVIII to which a biocompatible polymer may be attached to increase the circulatory half-life of the muteins, as well as conjugates of such muteins and biocompatible polymers.
Claims27
A modified FVIII protein comprising a cysteine substitution mutation at an amino acid corresponding to a position in the amino acid sequence of SEQ ID NO:1 selected from the group of amino acid positions consisting of:
- 2094, 2186, 2204, 2206, 59, 239, 333, 336, 379, 481, 484, 486, 488, 489, 490, 492, 493, 495, 496, 497, 499, 500, 501, 507, 555, 562, 568, 571, 582, 1680, 1778, 1793, 1794, 1797, 1798, 1799, 1800, 1801, 1806, 1810, 1811, 1814, 1816, 1818, 1891, 2035, 2068, 2092, 2093, 2095, 2118, 2125, 2183, 2191, 2196, and 2212.
Dependencies are inferred from the claim text.