Hydrogelators comprising d-amino acids
AssigneeBrandeis University
InventorsBing XU, Jiayang LI, Kuang YI
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Abstract
Described herein are compounds comprising an oligopeptide and a non-steroidal antiinflammatory agent. The compounds self-assemble into supramolecular hydrogels and can be used as topical treatments for inflammatory conditions, such as osteoarthritis. Also described herein are oligopeptides compounds made from D-amino acid residues that form supramolecular hydrogels. The compounds may be functionalized with active agents, such as anticancer therapeutic agents, antiinflammatory agents, or imaging agents, therefore providing new mechanisms for delivery of active agents.
Claims54
A hydrogelator of Formula III
- or a pharmaceutically acceptable salt thereof,
- wherein, independently for each occurrence,
- A is selected from the group consisting of
- R is H or alkyl;
- R1 is aralkyl, heteroaralkyl, hydroxyaralkyl, or phosphorylated aralkyl;
- R2 is H, aralkyl, heteroaralkyl, hydroxyaralkyl, phosphorylated aralkyl, alkyl, aminoalkyl, HO2C-alkyl, hydroxyalkyl, H2NC(═O)-alkyl, or HS-alkyl;
- n is 1, 2, 3, or 4;
- and
- m is 0, 1, 2, 3, or 4.
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A hydrogelator of Formula IV
- or a pharmaceutically acceptable salt thereof,
- wherein, independently for each occurrence,
- R is H or alkyl;
- R1 is aralkyl, heteroaralkyl, hydroxyaralkyl, or phosphorylated aralkyl;
- R3 is H, aralkyl, heteroaralkyl, hydroxyaralkyl, phosphorylated aralkyl, alkyl, aminoalkyl, HO2C-alkyl, hydroxyalkyl, H2NC(═O)-alkyl, HS-alkyl, or A-NR-alkyl, provided at least one instance of R3 is A-NR-alkyl;
- n is 1, 2, 3, or 4;
- p is 1, 2, 3, or 4;
- and
- A is selected from the group consisting of
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A hydrogelator selected from the group consisting of:
- wherein A is selected from the group consisting of
- or a pharmaceutically acceptable salt thereof.
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Dependencies are inferred from the claim text.