Leptospira With Increased Antigenic Mass
AssigneeIntervet Inc.
InventorsChristian Theodoor Gerardus Smits, Edwin Kets, Henriette Adriaanse
Life of this patent
Estimating the term…
Abstract
The antigenic mass of Leptospira cultures can be significantly increased, independent from any increase in biomass, by supplementing Leptospira cultures with a specific type of fatty acid: a polyunsaturated C18 fatty acid. This provides advantages in the production Leptospira antigens. Also this enables the production of improved Leptospirosis vaccines, that are safer and more effective.
Claims15
1-12. (canceled)
A method for increasing the antigenic mass of a Leptospira culture comprising the step of supplementing said Leptospira culture with a polyunsaturated C18 fatty acid.
A method for producing a vaccine against Leptospirosis comprising the steps of:
- a. proliferating a Leptospira culture in an in vitro system,
- b. supplementing said Leptospira culture with a polyunsaturated C18 fatty acid,
- c. inactivating and harvesting said supplemented Leptospira culture, and
- d. admixing the inactivated Leptospira culture with a pharmaceutically acceptable carrier.
A method for increasing the antigenic mass of a Leptospira culture comprising the step of supplementing said Leptospira culture with a compound or composition that is relatively rich in a polyunsaturated C 18 fatty acid.
Dependencies are inferred from the claim text.