Hemoglobin receptor as novel vaccine for leishmaniasis
AssigneesIndian Institute of Chemical Biology, National Institute of Immunology
InventorsAmitabha MUKHOPADHYAY, Syamal ROY, Deepika GUPTA, Rajan GUHA, Ruchir RASTOGI
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Abstract
The present invention in general relates Hemoglobin receptor or its part as a novel vaccine candidate against Leishmaniasis. Specifically, the present invention envisages HbR DNA for eliciting immune response in a mammal against Leishmaniasis. Additional aspect of the present invention is related to a vaccine composition for inducing immune response against Leishmaniasis in mammals. In a preferred aspect, the present invention relates to use of HbR-polypeptide as marker for diagnosis of Leishmania in kala-azar patients.
Claims12
A HbR-DNA for inducing sterile protection against virulent Leishmania, wherein said DNA comprises nucleotide sequence selected from the group consisting of:
- a) nucleotide sequence as set forth in any one of SEQ ID NO:
- 1 (HbR-FL), SEQ ID NO:
- 2 (HbR-N) or fragments thereof;
- b) a nucleotide sequence that encodes polypeptide having amino acid sequence as set forth in SEQ ID NO:
- 3.
A polypeptide selected from the group consisting of:
- a) a polypeptide comprising the amino acid sequence as set forth in SEQ ID NO:
- 3;
- b) a polypeptide that is encoded by the nucleotide sequence as set forth in any of SEQ ID NO:
- 1 or SEQ ID NO:
- 2;
- and c) a polypeptide that is a fragment of SEQ ID NO:
- 3.
Method for eliciting an immune response in mammals, comprising administering a vaccine composition as claimed in clams 6 to a mammal to be treated.
A HbR-polypeptide as marker for diagnosis of Leishmania in kala-azar patients, wherein said polypeptide is selected from the group consisting of a) a polypeptide comprising the amino acid sequence as set forth in SEQ ID NO:
- 3 or fragments thereof ;
- b) a polypeptide that is encoded by the nucleotide sequence as set forth in any of SEQ ID NO:
- 1 or fragments thereof.
Method for diagnosis of Leishmania in kala-azar patients which comprises determing the presence or absend of an HbR-polypeptide maker.
Dependencies are inferred from the claim text.