Modified fviii apitope peptides
AssigneeApitope International NV
InventorsDavid Wraith, Heather Streeter
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Abstract
The present invention provides peptides partly derivable from FVIII which are capable of binding to an MHC class II molecule without further antigen processing and being recognised by a factor VIII specific T cell. In particular, the present invention provides peptides comprising the sequence DNIMVTFRNQASRPY or PRCLTRYYSSFVNME with modifications at the N- and C-termini. The present invention also relates to the use of such a peptide for the prevention or suppression of inhibitor antibody formation in haemophilia A and/or acquired haemophilia.
Claims12
A peptide comprising the FVIII-derived sequence DNIMVTFRNQASRPY which peptide (a) has the formula
- XXGDNIMVTFRNQASRPYGXX
- wherein X is either Lysine or Glutamic acid;
- and
- (b) has one of the following sequences:
- (SEQ ID No. 17)
- KKGDNIMVTFRNQASRPYGKK
- (SEQ ID No. 18)
- KKGDNIMVTFRNQASRPYGKE
- (SEQ ID No. 19)
- KKGDNIMVTFRNQASRPYGEK
- (SEQ ID No. 25)
- KEGDNIMVTFRNQASRPYGKK
- (SEQ ID No. 26)
- KEGDNIMVTFRNQASRPYGKE
- (SEQ ID No. 27)
- KEGDNIMVTFRNQASRPYGEK
- (SEQ ID No. 29)
- EKGDNIMVTFRNQASRPYGKK
- (SEQ ID No. 30)
- EKGDNIMVTFRNQASRPYGKE
- and
- (SEQ ID No. 31)
- EKGDNIMVTFRNQASRPYGEK.
A peptide comprising the FVIII-derived sequence PRCLTRYYSSFVNME which peptide (a) has the formula
- XXGPRCLTRYYSSFVNMEGXX
- wherein X is either Lysine or Glutamic acid;
- and
- (b) has one of the following sequences:
- (SEQ ID No. 1)
- KKGPRCLTRYYSSFVNMEGKK
- (SEQ ID No. 2)
- KKGPRCLTRYYSSFVNMEGKE
- (SEQ ID No. 3)
- KKGPRCLTRYYSSFVNMEGEK
- (SEQ ID No. 5)
- EEGPRCLTRYYSSFVNMEGKK
- (SEQ ID No. 7)
- EEGPRCLTRYYSSFVNMEGEK
- (SEQ ID No. 9)
- KEGPRCLTRYYSSFVNMEGKK
- (SEQ ID No. 10)
- KEGPRCLTRYYSSFVNMEGKE
- (SEQ ID No. 11)
- KEGPRCLTRYYSSFVNMEGEK
- and
- (SEQ ID No. 13)
- EKGPRCLTRYYSSFVNMEGKK.
A composition comprising a plurality of peptides, including one or more peptide(s) according to claim or 2.
Dependencies are inferred from the claim text.