Loading patent…
AssigneeUniversity of Cincinnati
InventorsAlex B. Lentsch, Michael J. Edwards, Erich Gulbins
Estimating the term…
A pharmaceutical composition containing (1) a therapeutically effective amount of hepatocyte-derived exosomes; and (2) a pharmaceutically-acceptable carrier is provided. Also provided herein is a method of inducing liver regeneration in a patient in need thereof, the method including administering to the patient a therapeutic amount of hepatocyte-derived exosomes, wherein liver regeneration is induced. Methods for up-regulating synthesis of synthesis of sphingosine-1-phosphate (S1P) in a hepatocyte by contacting the hepatocyte with at least one vesicle containing sphingosine kinase 2, and, optionally, ceramide and neutral ceramidase, are also disclosed.
A pharmaceutical composition comprising:
A pharmaceutical composition formulated for targeted delivery to hepatocytes, the composition comprising ceramide, neutral ceramidase, and sphingosine kinase 2.
A method of inducing liver regeneration in a patient in need thereof, the method comprising administering to the patient a therapeutic amount of exosomes, whereby liver regeneration is induced, and wherein a therapeutic amount is defined as an amount at least sufficient to result in a detectable increase in liver mass.
A method of up-regulating synthesis of sphingosine-1-phosphate (S1P) in a hepatocyte, the method comprising contacting the hepatocyte with at least one vesicle containing sphingosine kinase 2, and, optionally, ceramide and neutral ceramidase.
Dependencies are inferred from the claim text.