Cyclic peptides and use as medicines

A compound of Formula I:

• or a pharmaceutically acceptable salt thereof, wherein
• A-B is —CH═CH or CH2CH2;
• R1 is C1-C4alkoxy or C1-C4 alkyl;
• R2 is —OR1a, or a 4 to 8 membered heterocycle containing 1 to 3 heteroatoms selected from N, S, and O, wherein said heterocycle is optionally substituted with at least one substituent selected from the group consisting of halogen, —OH, CN, —O(C1-C4)alkyl, oxo (═O), —S(O)2(C1-C4)alkyl, —C(O)(C1-C4)alkyl, —C(O)2(C1-C4)alkyl, C1-C4haloalkyl, C3-C7cycloalkyl, and C1-C4 alkyl optionally substituted with C1-C4alkoxy;
• R1a is C1-C4alkyl, (C1-C4)alkyl-OH, (C1-C4)alkyl-C1-C4alkoxy, (C2-C4)alkyl-NR9R10, a 4 to 8 membered heterocycle containing 1 to 3 heteroatom selected from N, S, and O, or a (C1-C4)alkyl-4 to 8 membered heterocycle containing 1 to 3 heteroatoms selected from N, S, and O, wherein said heterocycles are optionally substituted with at least one substituent selected from the group consisting of halogen, —OH, CN, —O(C1-C4)alkyl, oxo (═O), —S(O)2(C1-C4)alkyl, —C(O)(C1-C4)alkyl, —C(O)2(C1-C4)alkyl, C1-C4haloalkyl, C3-C7cycloalkyl, and C1-C4 alkyl optionally substituted with C1-C4alkoxy;
• R3 is C1-C6alkyl optionally substituted with at least one substituent selected from the group consisting of OH, O(C1-C4alkyl), —NR7R8, and S(C1-C6 alkyl);
• R4 is C1-C4 alkyl;
• R5 is H, (C1-C6)alkyl;
• R7 is H or C1-C4 alkyl;
• R8 is H or C1-C4 alkyl;
• or
• R7 and R8 taken together with the nitrogen to which they are attached form a 4 to 8 membered heterocycle containing 1 to 3 heteroatoms selected from N, S, and O, wherein said heterocycle is optionally substituted with at least one substituent selected from the group consisting of halogen and C1-C4 alkyl;
• R9 is H, C1-C4alkyl optionally substituted with one or more halogen, one or more hydroxy, C1-C4alkoxy, 5 to 6 membered heteroaryl or 5 to 6 membered heterocycle;
• and
• R10 is H, C1-C4alkyl optionally substituted with one or more halogen, C1-C4alkoxy or one or more hydroxy.