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US 2015/0306168 A1Published application
Methods of protecting against apoptosis using lipopeptides
AssigneesThe Cleveland Clinic Foundation, Cleveland BioLabs, Inc.
InventorsAlexander Shakhov, Andrei Gudkov
Life of this patent
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Abstract
The use of lipopeptides as inducers of NF-κB for the protection of mammals from the effects of apoptosis is described.
Claims16
-21. (canceled)
A method for activating a Toll-like receptor (TLR) in a cell, comprising contacting the cell with a composition comprising a compound of the formula:
- wherein,
- R1 represents H or —CO—R4;
- R2, R3, and R4 independently are H or optionally substituted C6-C20 aliphatic;
- X is a peptide comprising a sequence selected from SEQ ID NOs:
- 17, 20, or 21;
- and
- Z is S or CH2.
4 more elements
Dependencies are inferred from the claim text.