Back to results
US 2015/0306140 A1Published application
Induced activation in dendritic cells
AssigneeBaylor College of Medicine
InventorsDavid SPENCER, Brent HANKS, Kevin SLAWIN
Life of this patent
Estimating the term…
Abstract
The present invention is directed to a composition and method which to treat diseases and to enhance a regulated immune response. More particularly, the present invention is drawn to compositions that are based on dendritic cells modified to express an inducible form of a co-stimulatory polypeptide.
Claims14
1-18. (canceled)
A cell comprising a nucleic acid, wherein the nucleic acid comprises a promoter operably linked to a polynucleotide that encodes a chimeric protein, wherein the chimeric protein comprises
- a) a membrane targeting region;
- b) a multimeric ligand binding region;
- and
- c) a CD40 polypeptide cytoplasmic region wherein the CD40 polypeptide does not have a functional extracellular domain.
1 more element
Dependencies are inferred from the claim text.