Use of ivermectin and derivatives thereof
AssigneeRoivant Hepatology Ltd.
InventorsYong LI, Lihua JIN, Xuhui FENG
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Abstract
The present invention relates to the new use of antiparasitic agents, such as ivermectin, abamectin/avermectin, doramectin and so on, and the design method of the derivatives for the new use. The said compounds including macrolide abamectin/avermectin, ivermectin, doramectin and the derivatives thereof, may be used in the manufacture of a medicament for use in treating metabolic related diseases in a mammal, such as hyperglycemia, insulin resistance, hypertriglyceridemia, hypercholesterolemia, diabetes, obesity, etc, and Famesoid X receptor mediated diseases, such as cholestasia, gallstone, non alcohol fatty liver disease, atherosclerosis, inflammation, cancer, etc.
Claims9
1-15. (canceled)
A method of treating a Farnesoid X receptor mediated disease comprising administering to a patient a composition comprising ivermectin or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient.
A method of treating a Farnesoid X receptor mediated disease comprising administering to a patient a composition comprising avermectin or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient.
A method of treating a Farnesoid X receptor mediated disease comprising administering to a patient a composition comprising doramectin or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient.
A method of treating a Farnesoid X receptor mediated disease comprising administering to a patient a derivative of ivermectin, avermectin, or doramectin having Formulas (I), (II) or (III)
- or a pharmaceutically acceptable salt thereof, wherein the carbon-carbon double bonds at the sites C3-C4, C8-C9, C10-C11, C14-C15 and C22-C23 are modified, the hydroxy at the sites C5, C7 and C4″ are modified, and the side chains at the sites C4, C12, C14, C24 and C25 are modified, the glycosyl at the site C13 is hydrolyzed, and other groups are substituted;
- and a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.