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US 2015/0306114 A1Published application
Cyclic Amines
AssigneeH. Lundbeck A/S
InventorsJohn Paul Kilburn, Lars Kyhn Rasmussen, Mikkel Jessing, Eman Mohamed Eldemenky, Bin Chen, Yu Jiang
Life of this patent
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Abstract
The present invention is directed to novel cyclic amines which inhibit the P2X7 receptor.
Claims19
-24. (canceled)
A method of treating pain comprising administering a therapeutically effective amount of at least one compound of formula I
- wherein R1 is pyrimidyl optionally substituted with one or more C1-6 alkyl, halogen, hydroxy, C1-4fluoroalkyl, C3-6cycloalkyl, C1-6 alkoxy, C1-6fluoroalkoxy, cyano or —SO2R7;
- wherein R2a and R2b combine with the nitrogen to which they are attached to form piperazinyl, piperidinyl, morpholinyl, pyrrolidinyl, pyrrolo, imidazo, azetidinyl, 6 to 10 membered spiro(heterocyclyl), homomorpholinyl, homopiperidinyl or homopiperazinyl each of which is optionally substituted with one or more C1-6 alkyl, C1-6 alkenyl, C3-6-cycloalkyl, C1-6 alkoxy, oxo, —NR5R6 or fluorines;
- wherein R3 is halogen, C1-4fluoroalkyl, cyano, cyclopropyl, C1-4alkyloxy, C1-4fluoroalkyloxy, —SO2R7, —NR5R6 or C1-6alkyl;
- wherein R4 is halogen, C1-6 alkyl, C1-4fluoroalkyl, cyano, —SO2R8, —NR5R6, C1-6 alkoxy, C1-4fluoroalkoxy or C3-6-cycloalkyl;
- wherein R5 and R6 independently of each other are hydrogen or C1-6 alkyl;
- wherein R7 is C1-6 alkyl, C3-6cycloalkyl, C1-4fluoroalkyl and
- wherein n is 0-3;
- or a pharmaceutically acceptable salt thereof.
5 more elements
Dependencies are inferred from the claim text.