SAA Derivative Compound Restores eNOS And Inhibits Oxidative Stress-Induced A Diseases In Hypoxia

A method for inhibiting a disorder caused by oxidative stress in a subject, comprises a step of:

• administering to the subject suffering the disorder an effective amount of a composition comprises an ingredient being one of an SAA derivatives compound and an SAA complex compounds, wherein:
• the SAA derivatives compound is represented by formula I,
• the SAA complex compounds is represented by formula II,
• Rm is one selected from a group consisting of a first hydrogen, a first C1-C6 alkyl group, a first C1-C6 alkoxyl group and a 3-membered to 8-membered ring, and either one of R1 and Ra is classified into one of a category I and a category II, and wherein:
• in category I, R1 is one selected from a group consisting of a second hydrogen, a first halogen, a second C1-C6 alkyl group, a first C1-C5 alkoxyl group:
• and
• a first benzene ring having one or more substitute group selected from a second C1-C5 alkoxyl group, a first nitro group, a second halogen, a halogen substitute C1-C5 alkoxyl group and a halogen substitute C1-C6 alkyl group, and Ra is a xanthine group having a substitute of a fourth C1-C5 alkyl group, a third C1-C5 alkoxyl group and a third halogen.
• in category II, R1 is one of a second benzene ring having a substitute being one of a fourth C1-C5 alkoxyl group and a sulfonyl phenyl group and a heterocyclic ring having a substitute being one of a second C1-C6 alkoxyl group and a third C1-C6 alkyl group, and Ra is one selected from a group consisting of a third hydrogen, a second halogen, an amino group, a second nitro group, a second C1-C5 alkyl group and a fifth C1-C5 alkoxyl group,
• the heterocyclic ring is one selected from a group consisting of pyrazolo, pyrimidin, imidazo, pyrollidinyl, triazin and a fused ring having at least one selected from the group consisting of pyrazolo, pyrimidin, pyrollidinyl, imidazo and triazin, −RX is a carboxylic group having a negative charge, and the carboxylic group is donated from one selected from a group consisting of a plant acid, a substituted-sulfonic acids, a oxygen-containing acid (oxyacid), a non-steroid anti-inflammatory (NSAIDs), an anti-asthmatic drug, sodium carboxymethylcellulose, a γ-polyglutamic acid derivatives, a biodegradable polymers and a combination thereof.