Protein kinase c inhibitors and uses thereof

A method of inhibiting a protein kinase C (PKC) activity comprising contacting a PKC with a compound of formula (I):

• wherein
• R11 is selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, hydroxy, alkoxy, substituted alkoxy, amino, substituted amino, carboxyl, carboxyl ester, cyano, halogen, acyl, aminoacyl, nitro, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, sulfide, substituted sulfide, and SF5;
• Y1 and Y2 are independently selected from hydrogen and alkyl;
• and
• Ar1 is selected from aryl, substituted aryl, heteroaryl, and substituted heteroaryl;
• or a salt or stereoisomer thereof.