An Indolinone Derivative As Tyrosine Kinase Inhibitor

A compound represented by general formula (I), a pharmaceutically acceptable salt, a deuteride or a stereoisomer thereof:

• wherein, X represents O or S;
• R1 represents H or a prodrug group thereof;
• R2, R4 and R5 each independently represent H, hydroxy, amino, halogen, C1-6alkyl or C1-6alkyloxy;
• R3 represents H, carboxyl, or C1-6alkyl-OC(O)—, C1-6alkyl-SC(O)—, 3-14-membered cycloalkyl-OC(O)—, carbamoyl, C1-3alkylcarbamoyl, di(C1-3alkyl)carbamoyl, 6-14-membered aryl-OC(O)—, or 6-14-membered aryl(C1-3alkyl)-OC(O)—, which is unsubstituted or substituted by 1-3 groups represented by Q1,
• Q1 represents halogen, hydroxy, amino, 6-14-membered aryl, 3-14-membered cycloalkyl, 3-14-membered heterocyclyl, carboxyl, C1-3alkyloxy, C1-3alkyloxycarbonyl, C1-3alkylamino, di(C1-3alkyl)amino, carbamoyl, C1-3alkylcarbamoyl or di(C1-3alkyl)carbamoyl;
• R6 represents H, or C1-6alkyl, 3-14-membered cycloalkyl, 6-14-membered aryl, 7-12-membered bridged ring group-C0-3alkyl, 7-12-membered spiro ring group-C0-3alkyl or 3-14-membered heterocyclylC0-3alkyl, which is unsubstituted or substituted by 1-3 groups represented by Q2,
• Q2 represents halogen, hydroxy, cyano, carboxyl, amino, nitro, trifluoromethyl, C1-3alkyl, C1-3alkyloxy, hydroxyC1-3alkyl, aminoC1-3alkyl, C1-3alkyloxyC1-3alkyl, carboxylC1-3alkyloxy, C1-3alkylamino, di(C1-3alkyl)amino, C1-3alkyloxycarbonyl, carbamoyl, C1-3alkylcarbamoyl, di(C1-3alkyl)carbamoyl, C1-3alkylcarbonylamino, N-(C1-3alkyl)C1-3alkylcarbonylamino, C1-3alkylsulfonylamino, N-(C1-3alkyl)C1-3alkylsulfonylamino, or 6-14-membered arylC1-3alkylsulfonylamino;
• R7 represents H, or C1-3alkyl, 3-14-membered cycloalkyl, or 3-14-membered heterocyclyl, which is unsubstituted or substituted by 1-3 groups represented by Q3;
• Ring A represents phenyl or 5-7-membered heterocyclyl;
• R8 represents formula (IIa),
• wherein,
• Ra, Rb, Rc and Rd each independently represent H, C1-3alkyl, C1-3alkyloxy, amino, C1-3alkylamino, di(C1-3alkyl)amino, phenylamino, N-(C1-3alkyl)phenylamino, benzylamino, or N-(C1-3alkyl)benzylamino,
• Re represents H, C1-3alkyl, C1-3alkyloxy, amino, C1-3alkylamino, di(C1-3alkyl)amino, phenylamino, N-(C1-3alkyl)phenylamino, benzylamino, N-(C1-3alkyl)benzylamino, phenyl, or 3-8-membered monocyclic heterocyclyl,
• the carbon atom on the 3-8-membered monocyclic heterocyclyl can be replaced with 1-3 same or different groups selected from S(O)m and C(O),
• the C1-3alkyl and the 3-8-membered monocyclic heterocyclyl can be substituted by 1-3 groups as represented by Q3;
• Q3 represents halogen, hydroxy, cyano, carboxyl, amino, nitro, trifluoromethyl, C1-3alkyl, C1-3alkyloxy, di(C1-3alkyl)amino, C1-3alkyloxycarbonyl, carbamoyl, C1-3alkylcarbamoyl, di(C1-3alkyl)carbamoyl or C1-3alkylcarbonylamino;
• R9 represents H, halogen, hydroxy, cyano, carboxyl, amino, nitro, C1-3alkyl, trifluoromethyl, C1-3alkyloxy, C1-3alkyloxycarbonyl, acetamido, C1-3alkylsulfonylamino, carbamoyl, C1-3alkylcarbamoyl, di(C1-3alkyl)carbamoyl, aminosulfonyl, C1-3alkylaminosulfonyl or di(C1-3alkyl)aminosulfonyl;
• a and b each independently represent 0, 1, 2 or 3;
• n represents 0, 1 or 2, when n is 2, the substituents represented by R9 can be identical or different;
• n1 represents 0, 1, 2 or 3;
• n2 represents 0 or 1;
• n3 represents 0, 1, 2 or 3;
• m represents 1 or 2.