Aldosterone synthase inhibitors
AssigneeMerck Sharp & Dohme Corp.
InventorsAmjad Ali, Emmanuel Bey, Rolf Hartmann, Quingzhong Hu, Lina Yin
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Abstract
This invention relates to tricyclic triazole compounds or their pharmaceutically acceptable salts. The inventive compounds selectively inhibit aldosterone synthetase. This invention also provides for pharmaceutical compositions comprising the above-cited compounds or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthetase.
Claims10
A compound of the formula:
- or a pharmaceutically acceptable salt thereof.
A method for inhibiting CYP11B2 in a mammal in need thereof which comprises administering to said mammal an effective amount of a compound of the formula:
- or a pharmaceutically acceptable salt thereof
Dependencies are inferred from the claim text.