Modulating certain tyrosine kinases

A method comprising steps of:

• administering to a subject suffering from or susceptible to an ALK-associated condition a compound of formula I in combination with an additional chemotherapeutic agent.

A method comprising steps of:

• i. detecting in a subject an ALK-inhibitor resistance-associated marker;
• and
• ii. determining that the subject is a candidate for therapy with a compound of formula I.

A method comprising steps of:

• i. detecting in a subject an ALK-inhibitor resistance-associated marker;
• ii. determining that the subject is a candidate for therapy with a compound of formula I, and
• iii. administering to the patient a therapeutically effective amount of a compound of formula I.

A method of treating a TRK-associated condition, the method comprising administering to a patient in need thereof a compound of formula I.

A method of treating an ALK-associated condition, the method comprising administering to a patient in need thereof a compound of formula I, wherein the ALK-associated condition is a localized or present in the central nervous system.