Composition comprising a single variable domain and camostat mesylate (cm)
AssigneeGlaxo Group Limited
InventorsSean Matthew CLEVELAND, Stefan SALOMON, Cassandra VAN KRINKS
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Abstract
The present disclosure provides a means of stabilising a single variable domain, in particular in protease-rich environments such as the stomach and intestine. A composition, in particular a pharmaceutical composition, comprising a single variable domain and camostat mesylate is provided, together with uses of said composition as a medicament and in methods of treatment. Compositions of the disclosure are particularly useful in the topical treatment of gastrointestinal conditions, such as Crohn's Disease or ulcerative colitis, or for direct activity in the gut mucosal immune system.
Claims13
A composition comprising camostat mesylate and a single variable domain.
2-3. (canceled)
9-12. (canceled)
A method of stabilising a single variable domain in a protease-rich solution comprising formulating the single variable domain in a composition comprising camostat mesylate prior to exposing the composition to a protease-rich solution.
(canceled)
Dependencies are inferred from the claim text.