Quadruple therapy useful for treating persons afflicted with the human immunodeficiency virus (hiv)

Electronic portable pillbox comprising at least:

• a dispensing system comprising a retainer sheet and a dispending sheet comprising a plurality of dose containers, each dose container defining an opening closed by the retainer sheet
• a retainer sheet configured to burst proximate to each opening as the dose is dispensed through the respective openings of the containers;
• at least one sensor connected to each dose container;
• a software which is configured to record a time signal at each instance when a one dose is dispensed;
• a wireless data communications means allowing communication between the electronic portable pillbox and a remote device;
• said dose container comprising four active principles selected from:
• one nucleoside inhibitor of reverse transcriptase (NRTI) selected from lamivudine and emtricitabine;
• two different nucleoside or nucleotide inhibitors of reverse transcriptase (NRTI):
• didanosine, abacavir and tenofovir;
• the fourth active principle is selected from:
• (i) a non-nucleoside inhibitor of reverse transcriptase (NNRTI) selected from nevirapine, efavirenz and etravirine;
• or
• (ii) a protease inhibitor (PI) selected from atazanavir, lopinavir, saquinavir, ritonavir, indinavir, amprenavir, nelfinavir, fosamprenavir, tipranavir and darunavir.