# US 2015/0305974 A1 · Methods and devices for treating hypertension

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- Number: US 2015/0305974 A1
- Document ID: US20150305974A1
- Status: Published application
- Kind: A1
- Application number: 14/694,767
- Filed: 2015-04-23
- Published: 2015-10-29
- Earliest claimed: 2014-04-24
- Assignees: Sympara Medical, Inc.
- Applicants: Sympara Medical, Inc.
- Inventors: Kevin Joe Ehrenreich; Randolf von Oepen; William Rehlich; Kelly Justin McCrystle
- Web page: https://patentgrep.com/patent/US20150305974A1

## CPC

- A61H 23/0236: {using sonic waves, e.g. using loudspeakers}
- A61B 5/6833: {Adhesive patches}
- A61H 23/004: {With mechanical drive, e.g. spring mechanism or vibrating unit being hit for starting vibration and then applied to the body of a patient}
- A61H 23/0245: {with ultrasonic transducers, e.g. piezoelectric}
- A61H 23/04: with hydraulic or pneumatic drive {(hydraulic or Pneumatic massages, A61H9/00; underwater massages, A61H33/00)}
- A61B 5/02208: {using the Korotkoff method}
- A61B 5/4812: {Detecting sleep stages or cycles}
- A61B 5/6843: {Monitoring or controlling sensor contact pressure}
- A61B 2562/0219: Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
- A61H 2201/1619: Thorax
- A61H 2201/1647: the anatomy of a particular individual
- A61H 2201/165: Wearable interfaces
- A61H 2201/1654: Layer between the skin and massage elements, e.g. fluid or ball
- A61H 2201/5015: using specific interfaces or standards, e.g. USB, serial, parallel
- A61H 2201/5035: Several programs selectable
- A61H 2201/5043: Displays
- A61H 2201/5048: Audio interfaces, e.g. voice or music controlled
- A61H 2201/5061: Force sensors
- A61H 2201/5069: Angle sensors
- A61H 2201/5082: Temperature sensors
- A61H 2201/5084: Acceleration sensors
- A61H 2201/5092: Optical sensor
- A61H 2201/5097: wireless
- A61H 2230/045: used as a control parameter for the apparatus
- A61H 2230/065: used as a control parameter for the apparatus
- A61H 2230/208: used as a control parameter for the apparatus
- A61H 2230/305: used as a control parameter for the apparatus (A61H2230/045 takes precedence)
- A61H: PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY (electrotherapy, magnetotherapy, radiation therapy or ultrasound therapy A61N)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

Devices, systems and methods are described which control blood pressure and nervous system activity by stimulating baroreceptors. By selectively and controllably activating baroreceptors and/or nerves, the present disclosure, according to some embodiments reduces blood pressure and alters the sympathetic nervous system; thereby minimizing deleterious effects on the heart, vasculature and other organs and tissues. A baroreceptor activation device or other sensory activation device is positioned near a dermal bone to provide the treatment.

## Claims

### Claim 1

A device for modulating blood pressure, comprising:
a vibration source configured to apply vibratory energy to the clavicle through the skin surface; and
a bandage comprising at least a first layer and a second layer, at least one of the layers having an aperture formed therethrough sized to receive a portion of the vibration source, the bandage being adapted to adhesively attach to a skin surface over a clavicle of a subject, wherein at least one of the layers comprises at least one biologically active compound, wherein the biologically active compound is spaced apart from the vibration source forming a biologically compound-free area on the skin when the bandage is attached to the skin surface.

### Claim 2 (depends on 1)

The device of claim 1, wherein the biologically active compound comprises an anti-hypertensive agent.

### Claim 3 (depends on 2)

The device of claim 2, wherein the anti-hypertensive agent is configured to be absorbed transdermally.

### Claim 4 (depends on 3)

The device of claim 3, wherein the anti-hypertensive agent comprises nitropaste.

### Claim 5 (depends on 3)

The device of claim 3, wherein the anti-hypertensive agent comprises clonidine.

### Claim 6 (depends on 1)

The device of claim 1, wherein the vibration source is configured to apply vibratory energy at a frequency of between about 35 Hz and about 150 Hz.

### Claim 7 (depends on 1)

The device of claim 1, wherein at least one of the first layer and the second layer of the bandage comprises an adhesive.

### Claim 8 (depends on 1)

The device of claim 1, wherein the adhesive forms a discontinuous layer.

### Claim 9 (depends on 8)

The device of claim 8, wherein the discontinuous layer comprises a plurality of spaced-apart strips.

### Claim 10 (depends on 8)

The device of claim 8, wherein the discontinuous layer comprises a plurality of spaced-apart dots.

### Claim 11

A device for modulating blood pressure, comprising:
a vibration source configured to apply vibratory energy to the clavicle through the skin surface; and
a bandage comprising at least a first layer and a second layer, at least one of the layers having an aperture formed therethrough sized to receive a portion of the vibration source, the bandage being adapted to adhesively attach to a skin surface over a clavicle of a subject, wherein at least one of the first layer and the second layer of the bandage comprises an adhesive forming a discontinuous layer comprising an adhesive-free zone.

### Claim 12 (depends on 11)

The device of claim 11, wherein the discontinuous layer comprises a plurality of spaced-apart strips.

### Claim 13 (depends on 11)

The device of claim 11, wherein the discontinuous layer comprises a plurality of spaced-apart dots.

### Claim 14

A method for modulating blood pressure, comprising:
positioning a device comprising a vibration source and at least one biologically-active compound on the skin surface of a patient;
activating the vibration source such that the vibration source modulates the patient's baroreceptors, thereby decreasing the blood pressure of the patient; and
absorbing the biologically-active compound transdermally through the skin surface of the patient.

### Claim 15 (depends on 14)

The method of claim 14, wherein the biologically active compound comprises an anti-hypertensive agent, and wherein absorbing the anti-hypertensive agent decreases the blood pressure of the patient.

### Claim 16 (depends on 14)

The method of claim 14, wherein the skin surface of a patient is proximate a clavicle of the patient.