Integrated device system and method for noninvasive corneal refractive corrections

A method for non-invasive combined corneal refractive correction procedures, the method comprising:

• providing an ortho-K lens specifically manufactured based on a topography of an individual cornea of a human eye and configured to reshape the individual cornea from a first configuration to a second configuration;
• and
• delivering laser pulses directly into an internal layer of the individual cornea, the individual cornea being in said second configuration, to perform photochemical crosslinking between collagen molecules in the internal layer of the individual cornea for the purpose of fixating the individual cornea in the second configuration by said laser pulses, the laser pulses being generated by a laser device comprising:
• a laser source, said laser source is structured to produce a radiation output in the form of light pulses,
• a scanner, said scanner is configured to distribute said light pulses in a predetermined pattern in a x-y plane which is substantially perpendicular to the optical axis, and
• a light focusing objective, said objective focuses on an internal space of a human cornea;
• and said objective delivers the said light pulses into said internal space within an internal layer of said cornea following a predetermined pattern.

A system for human corneal crosslinking, the system comprising:

• a laser light source configured to output radiation along an optical axis in the form of one of:
• a continuous light beam with wavelength in the UV-visible range of approximately 200 nm to 700 nm,
• light pulses with wavelength in the UV-visible range of approximately 200 nm to 700 nm, or
• light pulses with a wavelength of approximately 960 nm or higher;
• a scanner configured to distribute said radiation in a predetermined pattern in an x-y plane substantially perpendicular to the optical axis;
• and
• a light focusing objective configured to focus on an internal space within an internal layer of a human cornea and to deliver the output radiation into the internal space within the human cornea,
• wherein the output radiation is absorbed by a photo initiator which is administered onto a surface of the human cornea prior to laser irradiation, and
• wherein the output radiation has a wavelength equal to or smaller than the wavelength of the maximum absorption peak (λmax) of said initiator.