Drill guides for confirming alignment of patient-specific alignment guides

An orthopedic method comprising:

• intraoperatively nesting a three-dimensional patient-specific surface of a patient-specific alignment guide to a corresponding surface of the bone, the three-dimensional patient-specific surface being preoperatively configured to align the patient-specific alignment guide relative to the bone when nested to the corresponding surface in only one position, the patient-specific alignment guide including a first referencing hole and a second referencing hole;
• intraoperatively mounting a drill guide onto the patient-specific alignment guide by inserting first and second coupling members of the drill guide into the first and second referencing holes, respectively, and aligning corresponding drill openings of the first and second coupling members with the first and second referencing holes, respectively;
• intraoperatively confirming that the patient-specific alignment guide is aligned relative to a mechanical axis of the bone using an alignment confirmation feature of the drill guide;
• and
• drilling a hole into the bone through one of the drill openings after confirming that the patient-specific alignment guide is aligned relative to the mechanical axis of the bone.