Systems and methods for evaluation of neuropathologies

A method to evaluate the efficacy of a treatment for a neurological or neuropsychiatric disorder, comprising:

• selecting a profile category indicative of one or more aspects of cognitive or sensory functions associated with a neurological or neuropsychiatric disorder;
• presenting a sequence of stimuli to a subject undergoing a treatment to the neurological or neuropsychiatric disorder, the sequence of stimuli based on the selected profile category;
• acquiring physiological signals of the subject before, during, and after the presenting of the sequence of stimuli to produce physiological data;
• and
• processing the physiological data to generate an information set including one or more quantitative values associated with the selected profile category indicative of the efficacy of the treatment for the subject.

A system for evaluating neurological or neuropsychiatric disorders, comprising:

• a stimulus delivery device to produce a sequence of stimuli that is presented to a subject, wherein the stimuli includes at least one of a visual, auditory, olfactory, tactile, or gustatory stimulating medium;
• a sensor device interfaced to the subject to detect physiological signals exhibited by the subject before, during, and after a presentation of the sequence of stimuli, the sequence of stimuli based on a cognitive-sensory profile category indicative of one or more aspects of cognitive or sensory functions associated with a neurological or neuropsychiatric disorder;
• and
• a data processing system in communication with the sensor device and structured to include one or more memory units and one or more processors configured to process the physiological signals as physiological data to generate an information set including one or more quantitative values associated with the selected profile category, the one or more quantitative values including a quantitative score depicting a level of the subject's vulnerability to or progressive pathology of the neurological or neuropsychiatric disorder.