Synergistic Microbicidal Combinations
AssigneeRohm and Haas Company
InventorsMegan Anne Diehl, Eileen Fleck Warwick
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Abstract
Antimicrobial compositions based on the synergistic combination of 2-methyl-3-isothiazolone and selected commercial microbicides where the compositions are substantially free of halogenated 3-isothiazolone, are disclosed. Particularly preferred are combinations of 2-methyl-3-isothiazolone together with benzoic acid, citric acid, sorbic acid, 1,2-dibromo-2,4-dicyanobutane, 1,3-dimethylol-5,5-dimethylhydantoin, phenoxyethanol, benzyl alcohol, zinc pyrithione or climbazole, that provide enhanced microbicidal efficacy at a combined active ingredient level lower than that of the combined individual 3-isothiazolone and commercial microbicide effective use levels.
Claims15
1-10. (canceled)
A microbicidal composition consisting of 2-methyl-3-isothiazolone and 1,3-dimethylol-5,5-dimethylhydantoin which is effective for inhibiting growth of a bacterial microorganism, wherein either (a) the ratio of 2-methyl-3-isothiazolone to 1,3-dimethylol-5,5-dimethylhydantoin is from 1/0.06 to 1/6.7, and over such range the composition exhibits synergy for inhibiting growth of Staphylococcus aureus;
- (b) the ratio of 2-methyl-3-isothiazolone to 1,3-dimethylol-5,5-dimethylhydantoin is from 1/0.8 to 1/8, or 1/6.7 to 1/13, and over such range the composition exhibits synergy for inhibiting growth of Pseudomonas aeruginosa, or (c) the ratio of 2-methyl-3-isothiazolone to 1,3-dimethylol-5,5-dimethylhydantoin is from 1/1 to 1/6.7 and over such range the composition exhibits synergy for inhibiting growth of both Staphylococcus aureus and Pseudomonas aeruginosa.
Dependencies are inferred from the claim text.