Inhibition of Histone Methyltransferase for Cardiac Reprogramming
AssigneeDuke University
InventorsVictor J. Dzau, Maria Mirotsou
Life of this patent
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Abstract
A method for promoting the reprogramming of a non-cardiomyocytic cell or tissue into cardiomyocytic cell or tissue comprising is carried out by contacting a non-cardiomyocytic cell or tissue with a modulator of histone methyltransferase activity or expression.
Claims69
A method for promoting the reprogramming of a non-cardiomyocytic cell or tissue into cardiomyocytic cell or tissue comprising contacting said non-cardiomyocytic cell or tissue with a composition comprising a modulator of histone methyltransferase activity or expression.
A method for treating or reducing cardiac fibrosis comprising identifying a subject having or at risk of cardiac fibrosis and administering a modulator of histone methyltransferase activity or expression.
A method for regenerating cardiomyocytic cell or tissue comprising reprogramming of a non-cardiomyocytic cell or tissue into cardiomyocytic cell or tissue, wherein said reprogramming comprises contacting said non-cardiomyocytic cell or tissue with a modulator of histone methyltransferase activity or expression.
A composition promoting the reprogramming of a non-cardiomyocytic cell or tissue into cardiomyocytic cell or tissue comprising contacting said non-cardiomyocytic cell or tissue with a composition comprising a modulator of histone methyltransferase activity or expression.
Dependencies are inferred from the claim text.