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US 2015/0274732 A1Published application
Preparation of ertapenem intermediates
AssigneeSandoz Ltd.
InventorsHannes Lengauer, Birgit Endl, Wolfgang Felzmann
Life of this patent
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Abstract
The present invention relates to the preparation of compounds, in particular to the preparation of compounds which may be used as intermediates for the preparation of antibiotics, preferably carbapenem antibiotics, more preferably ertapenem, and salts thereof.
Claims19
A crystalline compound of formula (I) or a solvate thereof
- wherein the PG residues are each and independently a protective group, which is capable of protecting a carboxylic acid function.
(canceled)
-9. (canceled)
The process of claim 12
- further comprising a step a) of reacting a compound of formula (II),
- with a compound of formula (III) or a salt thereof,
- to obtain said compound of formula (IV) or a salt thereof
The process of claim 14,
- further comprising a step a) of reacting a compound of formula (II),
- with a compound of formula (III) or a salt thereof,
- to obtain a compound of formula (IV) or a salt thereof
- and a step b) of converting the compound of formula (IV) or a salt thereof to a compound of formula (I) or a solvate thereof
- wherein the PG residues are each and independently a protective group, which is capable of protecting a carboxylic acid function;
- and a step c) of crystallizing the compound of formula (I) or a solvate thereof from a solution of the compound of formula (I).
3 more elements
The process of claim 14,
- further comprising a step b) of converting a compound of formula (IV) or a salt thereof
- to a compound of formula (I) or a solvate thereof
- wherein the PG residues are each and independently a protective group, which is capable of protecting a carboxylic acid function;
- and a step c) of crystallizing the compound of formula (I) or a solvate thereof from a solution of the compound of formula (I).
1 more element
(canceled)
Dependencies are inferred from the claim text.