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US 2015/0272984 A1Published application
Agents for the prevention and/or treatment of central nervous system damage
AssigneesThe University of Liverpool, The University Court of the University of Glasgow
InventorsJeremy Ewan Turnbull, Scott Ernest Guimond, Sophie Marie Thompson, Susan Carol Barnett, Jennifer Rosemary Higginson
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Abstract
The present invention relates to the use of agents (including heparin derivatives) for the prevention and/or treatment of CNS damage.
Claims18
An agent for use in the prevention and/or treatment of CNS damage, wherein said agent is selected from the group consisting of:
- (i) a heparin derivative which is:
- substantially 2-O desulphated and 2-N desulphated;
- substantially 6-O desulphated and 2-N desulphated;
- substantially 2-O and 6-O desulphated;
- and/or
- substantially 2-O, 6-O and 2-N desulphated;
- (ii) an enzyme selected from:
- heparinase 1, 2 or 3;
- Sulf 1;
- and/or
- Sulf 2;
- (iii) a compound capable of increasing the activity of a heparinase, Sulf 1 and/or Sulf2 enzyme;
- (iv) a compound capable of increasing the expression of a Sulf 1 and/or Sulf2 enzyme;
- (v) a selective FGF-1 and/or FGF-9 inhibitor;
- (vi) an inhibitor of FGFR signalling pathways,
- or a pharmaceutically acceptable salt or solvate of said agent.
13 more elements
15-16. (canceled)
Dependencies are inferred from the claim text.