Methods of depleting antibodies directed towards major histocompatibility complex
AssigneesOxford Radcliffe Hospital Nhs ("Orh") Trust of the John Radcliffe Hospital, King's College London, Guy's & St. Thomas' Hospital Nhs Trust ("Gst")
InventorsMartin BARNARDO, Andrea Harmer, Michael Bunce, Robert Vaughan, Kenneth Welsh
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Abstract
The invention provides a method of depleting anti-MHC antibodies in a sample comprising contacting said sample with one or more recombinant MHC molecules or functionally equivalent variants, derivatives or fragments thereof and removing at least the recombinant MHC molecules to which antibodies to said recombinant MHC molecules contained within the sample have bound. This method allows the depletion of one or more specific MHC particularly HLA allele antibodies from a sample.
Claims12
A method of depleting anti-major histocompatibility complex (anti-MHC) antibodies in a sample, said method comprising contacting the sample with a peptide that is epitopic to said anti-MHC antibodies to create an anti-MHC/peptide complex and removing said complex from said sample, wherein said removal of said complex depletes said sample of said anti-MHC antibodies.
Dependencies are inferred from the claim text.