Nanocarriers And Their Processing For Diagnostics And Therapeutics
AssigneeRhode Island Hospital
InventorsQian Chen, Yupeng Chen, Hongchuan Yu, Michael G. Ehrlich
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Abstract
The compositions and methods of the invention provide compositions and methods for preferential targeting of tissues to delivery therapeutic or diagnostic agents. For example, such compounds are useful in the treatment of joint disorders those affecting articulating joints, e.g., injury-induced osteoarthritis as well as autoimmune diseases affecting joint tissue such as rheumatoid arthritis.
Claims28
A system for selective drug delivery to a bodily tissue comprising a rosette nanopiece composition comprising a cargo compound,
- wherein a positively-charged nanopiece composition with net positive charge at pH 7-7.5 localizes or penetrates a negatively-charged tissue;
- wherein a negatively-charged or weakly positively-charged nanopiece composition with net negative charge or weak positive charge at pH 7-7.5 localizes or penetrates a positively-charged tissue.
A method of treating joint disease comprising administration of an effective amount of a rosette nanopiece, wherein said nanopiece comprises a compound of Formula I or Formula II.
A method of diagnosing joint disease comprising administration of rosette nanopiece, wherein said nanopiece comprises a compound of Formula I or Formula II.
A method making a rosette nanotube-agent complex comprises:
- a. combining a self-assembled rosette nanotube and one or more agents, such as therapeutic or diagnostic agents, in media whereupon the one or more agents are incorporated into the rosette nanotube to form a complex of a rosette nanotube and one or more agents;
- or
- b. combining compounds of Formula I or II and one or more agents, such as therapeutic or diagnostic agents, in media where the compounds self-assemble into a rosette nanotube which incorporates the one or more agents to form a complex of a rosette nanotube and the one or more agents.
A system for selective drug delivery to a bodily tissue comprising a rosette nanopiece composition comprising a cargo compound, said composition being sized to localize or penetrate a target tissue,
- wherein a size of ≦100 nm in at least one dimension localizes or penetrates synovium, ocular tissue, dermatologic tissue, mucosal tissue, or pulmonary tissue;
- wherein a size of <90 nm in at least one dimension localizes or penetrates cartilage with inflammation or defect;
- wherein a size of ≦50 nm in at least one dimension localizes or penetrates kidney tissue;
- wherein a size of <30 nm in at least one dimension localizes or penetrates healthy, intact cartilage;
- or
- wherein a size of ≦20 nm in at least one dimension localizes or penetrates heart tissue.
A composition comprising a cargo molecule and a nanostructure comprising Formula I or Formula II for selective delivery of a therapeutic drug or diagnostic agent to a target bodily tissue.
Dependencies are inferred from the claim text.