Trabecular meshwork stem cells
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsYiqin Du, James L. Funderburgh, Joel Steven Schuman
Life of this patent
Estimating the term…
Abstract
Provided herein are isolated populations of multipotent stem cells capable of differentiating into trabecular meshwork (TM) cells, methods of obtaining an isolated population of TM cells, and isolated populations of TM cells obtained therefrom. Compositions, kits, and devices comprising the isolated populations of multipotent stem cells or TM cells are also provided herein. Further provided are methods of using the compositions, kits, and devices for decreasing intraocular pressure in an eye, increasing cell density in a trabecular meshwork of an eye, increasing outflow of aqueous humor from an eye, or treating or preventing a medical condition in a subject.
Claims11
1-30. (canceled)
A method of decreasing intraocular pressure in an eye, comprising administering to a subject in need of decreasing intraocular pressure in the eye a composition comprising an isolated population of multipotent stem cells which are capable of differentiating into trabecular meshwork (TM) cells and a pharmaceutically acceptable carrier, diluent, or excipient, in an amount effective to decrease the intraocular pressure in the eye.
A method of increasing cell density in a trabecular meshwork (TM) of an eye, comprising administering to a subject in need of increasing cell density in the trabecular meshwork of the eye a composition comprising an isolated population of multipotent stem cells which are capable of differentiating into trabecular meshwork (TM) cells and a pharmaceutically acceptable carrier, diluent, or excipient, in an amount effective to increase cell density in the TM.
A method of increasing outflow of aqueous humor from an eye, comprising administering to a subject in need of increasing outflow of aqueous humor from the eye a composition comprising an isolated population of multipotent stem cells which are capable of differentiating into trabecular meshwork (TM) cells and a pharmaceutically acceptable carrier, diluent, or excipient, in an amount effective to increase the outflow.
A method of treating or preventing a medical condition caused by or associated with decreased cell density in a trabecular meshwork of an eye, increased intraocular pressure in an eye, decreased outflow of aqueous humor from the eye, or a combination thereof, comprising administering to a subject with the medical condition a composition comprising an isolated population of multipotent stem cells which are capable of differentiating into trabecular meshwork (TM) cells and a pharmaceutically acceptable carrier, diluent, or excipient, in an amount effective to treat the medical condition.
40-44. (canceled)
Dependencies are inferred from the claim text.