Increased Production of Terpenes and Terpenoids
AssigneeEvolva SA
InventorsThomas Oestergaard Tange, Michael Naesby, Christophe Folly, Fanny Delegrange, Jens Houghton-Larsen, Simon Carlsen
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Abstract
This invention provides recombinant cells and methods for producing terpenes and terpenoids by increasing production or accumulation or both of isoprenoid precursors thereof.
Claims49
A method for producing a terpene or terpenoid in a recombinant host cell, the method comprising the steps of culturing under conditions wherein the terpene or terpenoid is produced in a genetically engineered cell having reduced expression of endogenous farnesyl diphosphate synthase, geranyl diphosphate synthase or an enzyme having both farnesyl diphosphate synthase and geranyl diphosphate synthase activity, and further comprising one or more recombinant expression constructs encoding heterologous enzymes for producing said terpene or terpenoid.
3-4. (canceled)
(canceled)
A recombinant cell for producing a terpene or terpenoid genetically engineered to have reduced expression of endogenous farnesyl diphosphate synthase, geranyl diphosphate synthase or an enzyme having both farnesyl diphosphate synthase and geranyl diphosphate synthase activity, and further comprising one or more recombinant expression constructs encoding heterologous enzymes for producing said terpene or terpenoid.
28-29. (canceled)
(canceled)
Dependencies are inferred from the claim text.