Bioactive glass scaffolds, and method of making
AssigneeMo-Sci Corporation
InventorSteven Jung
Life of this patent
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Abstract
A glass, glass-ceramic, or ceramic bead is described, with an internal porous scaffold microstructure that is surrounded by an amorphous shield. The shield serves to protect the internal porous microstructure of the shield while increasing the overall strength of the porous microstructure and improve the flowability of the beads either by themselves or in devices such as biologically degradable putty that would be used in bone or soft tissue augmentation or regeneration. The open porosity present inside the bead will allow for enhanced degradability in-vivo as compared to solid particles or spheres and also promote the growth of tissues including but not limited to all types of bone, soft tissue, blood vessels, and nerves.
Claims24
1-25. (canceled)
A shielded glass scaffold comprising
- A sintered 45S5 bioactive glass fibers and 45S5 bioactive glass beads, some of the fibers and beads being fused to one another to create a sintered, porous agglomerate.
A glass scaffold comprising two or more different glass compositions formed by mixing glass compositions selected from the group consisting of at least two glass fiber compositions and at least two glass bead compositions prior to thermal treatment to form a sintered agglomerate.
A method of preparing glass scaffolds comprising the steps of:
- 1) mixing bioactive glass beads with bioactive glass fibers to form compressible agglomerates;
- 2) sintering the agglomerates;
- and
- 3) cooling the sintered agglomerates at a rate of about 1000° C./min to about 200,000° C./sec and collecting the resulting shielded glass scaffolds.
A method of preparing glass scaffolds comprising the steps of:
- 1) forming bioactive glass agglomerates;
- 2) heating the bioactive glass agglomerates to about 900° C. to about 1100° C. at a rate of 800° C./min to about 200,000° C./sec;
- and
- 3) cooling the sintered agglomerates at a rate of about 1000° C./min to about 200,000° C./sec and collecting the resulting shielded glass scaffolds.
A method of preparing glass scaffolds comprising the steps of:
- 1) forming bioactive glass agglomerates;
- and
- 2) placing in a crucible and heating to about 900° C. to about 1100° C. for a period of about ten to about twenty minutes, and then cooling to form sintered agglomerates.
A method of preparing glass scaffolds comprising the steps of:
- 1) forming bioactive glass fiber and particles agglomerates;
- and
- 2) placing in a crucible and heating to above the glass transition temperature and below the glass melt temperature, and then cooling to form sintered agglomerates.
A method of preparing glass scaffolds comprising the steps of:
- 1) forming bioactive glass fibers and particle agglomerates from 45S5 bioactive glass;
- 2) sintering the agglomerates, and then cooling to form glass scaffolds, said cooling step being at a rate of about 1000° C./sec.
A method of preparing glass scaffolds comprising the steps of:
- 1) forming bioactive glass agglomerates;
- and
- 2) placing in a crucible and heating to about 900° C. to about 1100° C. for a period of about ten to about twenty minutes, and then cooling to form sintered agglomerates at a rate of about 1000° C./sec.
Dependencies are inferred from the claim text.