Pivka-ii measurement method, measurement reagent, and measurement kit
AssigneesEidia Co., Ltd., Fujirebio Inc.
InventorsKentaro Yamaguchi, Katsumi Aoyagi, Azusa Terao
Life of this patent
Estimating the term…
Abstract
Disclosed are a PIVKA-II measurement method that achieves better serum-plasma correlation than conventional methods, and a reagent and a kit therefor. The PIVKA-II measurement method according to the present invention comprises measuring PIVKA-II in a sample by an immunoassay using a mixture of an anti-F1 antibody that specifically binds to prothrombin fragment F1 or an antigen-binding fragment thereof and an anti-F2 antibody that specifically binds to prothrombin fragment F2 or an antigen-binding fragment thereof; and an anti-PIVKA-II antibody that specifically binds to PIVKA-II or an antigen-binding fragment thereof.
Claims8
A method for measuring PIVKA-II, comprising measuring PIVKA-II in a sample by carrying out an immunoassay using
- a mixture of an anti-F1 antibody that specifically binds to prothrombin fragment 1 or an antigen-binding fragment thereof, and an anti-F2 antibody that specifically binds to prothrombin fragment 2 or an antigen-binding fragment thereof;
- and
- an anti-PIVKA-II antibody that specifically binds to PIVKA-II or an antigen-binding fragment thereof.
An immunoassay reagent for PIVKA-II in a sample, said reagent comprising:
- an anti-PIVKA-II antibody that specifically binds to PIVKA-II or an antigen-binding fragment thereof;
- an anti-F1 antibody that specifically binds to prothrombin fragment F1 or an antigen-binding fragment thereof;
- and an anti-F2 antibody that specifically binds to prothrombin fragment F2 or an antigen-binding fragment thereof.
Dependencies are inferred from the claim text.