Mutations In Calmodulin Genes

2-15. (canceled)

An isolated polypeptide comprising calmodulin (CaM), or at least a part of a calmodulin protein (CaM), wherein said polypeptide comprises at least one mutation associated with a cardiac disorder.

17-35. (canceled)

A method for determining whether an individual has an increased risk of contracting a cardiac disorder or sudden cardiac death, wherein said method comprises

• determining the presence or absence of at least one mutation in CALM1 (SEQ ID NO:1), CALM2 (SEQ ID NO:2) and/or CALM3 (SEQ ID NO:3) and/or in a polynucleotide having at least 90% sequence identity with SEQ ID NO:1, SEQ ID NO:2 and/or SEQ ID NO:3 or part thereof in a sample from said individual and/or
• determining the presence or absence of at least one mutation in the polypeptide having SEQ ID NO:4 or at least 90% sequence identity with SEQ ID NO:4 or part thereof in a sample from said individual,
• wherein the presence of said at least one mutation indicates an increased risk of contracting a cardiac disorder.

(canceled)

(canceled)

A method for diagnosing a cardiac disorder of an individual, wherein said method comprises

• determining the presence or absence of at least one mutation in CALM1 (SEQ ID NO:1), CALM2 (SEQ ID NO:2) and/or CALM3 (SEQ ID NO:3) and/or in a polynucleotide having at least 90% sequence identity with SEQ ID NO:1, SEQ ID NO:2 and/or SEQ ID NO:3 or part thereof in a sample from said individual and/or
• determining the presence or absence of at least one mutation in the polypeptide having SEQ ID NO:4 or at least 90% sequence identity with SEQ ID NO:4 or part thereof in a sample from said individual,
• wherein the presence of said at least one mutation indicates a cardiac disorder or an increased risk of contracting a cardiac disorder.

40-43. (canceled)

A method for treatment of an individual having a cardiac disorder associated with at least one mutation in CALM1 (SEQ ID NO:1), CALM 2 (SEQ ID NO:2) and/or CALM3 (SEQ ID NO:3) and/or in a polynucleotide having at least 90% sequence identity with SEQ ID NO:1, SEQ ID NO:2 and/or SEQ ID NO:3 or part thereof, wherein said mutation results in the mutated calmodulin having one or more altered functional property compared to wild type calmodulin, said method comprising administering to said individual an agent capable of restoring and/or improving the altered functional property to the level in wild type calmodulin.

45-57. (canceled)

(canceled)

61-72. (canceled)

A pharmaceutical composition for use in the treatment of an individual having a cardiac disorder associated with at least one mutation in CALM1 (SEQ ID NO:1), CALM2 (SEQ ID NO:2) and/or CALM 3 (SEQ ID NO:3, wherein said mutation results in the mutated calmodulin having one or more altered functional property compared to wild type calmodulin, and wherein said composition comprises an agent capable of restoring and/or improving the altered functional property to the level in wild type calmodulin.

74-83. (canceled)

A kit for detecting at least one mutation in a polynucleotide encoding calmodulin (CaM), or at least a part of calmodulin (CaM), wherein said kit comprises at least one oligonucleotide that is complementary to a sequence of said calmodulin encoding gene such that if the mutation is present in the polynucleotide, strand elongation from said oligonucleotide results in an extension product comprising said mutation.

85-96. (canceled)