Loading patent…
AssigneeEvonik Roehm GmbH
InventorsAchim MARX, Markus Poetter, Stefan Buchholz, Alexander May, Hermann Siegert, Georg Fuchs, Birgit Alber, Lothar Eggeling
Estimating the term…
The present invention relates to a cell which has been modified in comparison with its wild type in such a way that it is capable of forming more, by comparison with its wild, 3-hydroxyisobutyric acid or polyhydroxyalkanoates based on 3-hydroxyisobutyric acid via methylmalonate-semialdehyde or 3-hydroxybutyryl-coenzyme A as precursors. The invention also relates to a method of generating a genetically modified cell, to the genetically modified cell obtainable by these methods, to a method of producing 3-hydroxyisobutyric acid or polyhydroxyalkanoates based on 3-hydroxyisobutyric acid, to a method of producing methacrylic acid or methacrylic esters, and to a method of producing polymethacrylic acid or polymethacrylic esters. The present invention furthermore relates to an isolated DNA, to a vector, to the use of this vector for transforming a cell, to a transformed cell, and to a polypeptide.
A cell which has been genetically modified in comparison with its wild type in such a way that it is capable of forming more 3-hydroxyisobutyric acid from L-valine, as a carbon source, in comparison with its wild type, wherein more 3-hydroxyisobutyric acid is formed from 3-hydroxyisobutyryl-coenzyme A as a precursor, wherein activities of enzymes E8, E60, E61, E79, and E80 are increased in the cell compared to its wild type, wherein:
Dependencies are inferred from the claim text.